Key points

  • Staging of myeloma helps to determine the extent of the disease and informs assessment of the likely prognosis
  • The R-ISS stages myeloma based on the following four factors:
    • β2M
    • Albumin
    • Presence or absence of high-risk chromosomal abnormalities
    • LDH
  • Staging myeloma together with other prognostic factors allows patients to be risk stratified. This can help give patients some idea of their prognosis and may help guide treatment decisions.
  • The prognosis of myeloma is an area of ongoing research and will continue to advance rapidly in the near future.