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Myeloma Nurse Learning Programme Module 5 – Treatment for myeloma Proteasome Inhibitors

Proteasome Inhibitors

Proteasome inhibitors (PI) work by preventing the work of proteasomes, which are structures within cells that degrade damaged or unwanted protein. Myeloma cells accumulate a lot of excess protein and without it’s removal the cell dies. Bortezomib (Velcade®) and carfilzomib (Kyprolis®) are the two most commonly used proteasome inhibitor drugs for the treatment of myeloma.

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