MNLP – Module 6 – Final assessment

1. Question

Match the following words with the correct type of transplantation.

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Allogeneic transplant
Autologous transplant

A transplant involving stem cells from a matched donor is known as an
A transplant involving the patient’s own stem cells is known as an

2. Question

Factors normally taken into account when determining the suitability of a patient for high-dose chemotherapy and stem cell transplantation include the following except

A. Age
B. Renal function
C. Lung and cardiac function
D. Body mass index
E. Patient preference

3. Question

Which of the following statements is not correct?

High-dose chemotherapy followed by stem cell transplantation is used to treat myeloma because it

A. Provides a greater depth of response than conventional chemotherapy
B. Provides a greater duration of response than conventional chemotherapy
C. Can enhance survival
D. Consolidates the response to induction treatment
E. Increases the ability of the bone marrow to produce blood cells

4. Question

Can you match the correct term in the sentence

Induction treatment is

A. Not necessary prior to a stem cell transplant
B. Treatment involving a high dose of chemotherapy
C. Treatment given prior to stem cell transplant
D. Treatment given after stem cell transplant

5. Question

The cells infused during a stem cell transplant are

A. Pluripotent stem cells
B. Haematopoietic stem cells
C. Bone marrow cells
D. Red blood cells
E. Embryonic stem cells

6. Question

Which new blood cells are stimulated to develop during the process of engraftment?

A. Red blood cells
B. Platelets
C. Neutrophils
D. Leucocytes
E. All of the above

7. Question

Can you match the correct words to the descriptions below?

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G-CSF
High-dose cyclophosphamide
Mozobil
DMSO

A. A synthetic growth factor which promotes the proliferation and release of stem cells
B. Reduces the number of stem cells temporarily and causes the bone marrow to go into stem cell proliferation overdrive
C. Given when sufficient number of stem cells cannot be mobilised by conventional means
D. A cryoprotectant harvested stem cells are mixed with when stored in liquid nitrogen

8. Question

The minimum number of stem cells needed for a transplant is

A. Half a million stem cells per kg body weight
B. One million stem cells per kg body weight
C. Two million stem cells per kg body weight
D. Three million stem cells per kg body weight
E. Five million stem cells per kg body weight

9. Question

The most common side-effect of apheresis is

A. Cramping or tingling sensation
B. Thirst
C. Nausea
D. Loss of appetite
E. Sore mouth

10. Question

Conditioning treatment involves patients receiving a

A. A high dose of Velcade
B. A high dose of melphalan
C. A high dose of dexamethasone
D. A high dose of vincristine
E. A high dose of G-CSF

11. Question

Which of the following is not normally considered a side-effect of high-dose therapy and stem cell transplantation?

A. Hair loss
B. Oral mucositis
C. Myelosuppression
D. Bone pain
E. Fatigue

12. Question

The aim of an allogeneic transplant is to generate

A. Histocompatability
B. Myeloablation
C. Immunosuppression
D. Graft versus host effect
E. Graft versus disease effect

13. Question

Assertion: The lining of the mouth, the digestive system, skin, hair and bone marrow are most likely to be affected by chemotherapy

BECAUSE

Reason: Chemotherapy particularly affects areas where normal cells are rapidly dividing

A. True True – reason correctly explains assertion
B. True True – both statements are true but the reason does not explain the assertion
C. True False
D. False True
E. False False

14. Question

Can you match the correct term in the sentence below?

A second transplant is

A. Usually given within six months of the first
B. Given as salvage treatment
C. Always an autologous transplant
D. Requires more stem cells to be collected
E. Followed by a donor lymphocyte infusion

15. Question

Assertion: All eligible myeloma patients undergo high-dose chemotherapy and stem cell transplantation

BECAUSE

Reason: Patients must achieve a partial response to induction treatment

A. True True – reason correctly explains assertion
B. True True – both statements are true but the reason does not explain the assertion
C. True False
D. False True
E. False False

16. Question

Can you match the correct term to the sentence below

The mortality rate for an autologous transplant is – X – the mortality rate for an allogeneic transplant

greater than
less than

17. Question

The upper age limit for a patient undergoing an autologous transplant is – X – the upper age limit for a patient undergoing an allogeneic transplant

greater than
less than

18. Question

It is recommended that transplant patients only receive irradiated blood products

A. True
B. False

19. Question

An autologous transplant is when the donor of the transplant is the sibling of the recipient of the transplant

A. True
B. False

20. Question

Which of the following statements is correct?

A tandem autologous transplant is

A. Also known as a double transplant
B. Offered to younger/fitter myeloma patients
C. Given at the time of relapse
D. Followed by maintenance treatment