BSH guideline on Early diagnosis of AL amyloidosis in haematology, cardiology, neurology, renal and general clinics
The British Society for Haematology has published a guideline on the early diagnosis of AL amyloidosis across haematology, cardiology, neurology, renal, and general clinics.
AL amyloidosis is caused by a plasma cell clone producing abnormal light chains. These light chains misfold and deposit as amyloid fibrils in tissues, which can affect organ function.
Why early diagnosis matters
The guideline highlights that outcomes for people with AL amyloidosis are strongly linked to the extent of organ damage at diagnosis. Early-stage AL amyloidosis is associated with markedly better survival than advanced disease.
However, AL amyloidosis can be difficult to recognise. It can present across different clinical settings, including haematology, cardiology, renal, neurology, general medicine, care of older people, and general practice.
Who is the guideline for?
The guideline is relevant to healthcare professionals who may see people with signs or symptoms suggestive of AL amyloidosis, including those working in:
- Haematology.
- Cardiology.
- Neurology.
- Renal medicine.
- General medicine.
- Primary care.
It includes guidance on when to suspect AL amyloidosis, recommended screening investigations, and when urgent haematology review should be considered.
Use Case
Type
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BSH Guideline
