GP Diagnostic Tool for Wales

Early diagnosis of myeloma depends on primary care teams recognising when symptoms and blood test abnormalities suggest myeloma rather than more common conditions. GPs need clear guidance on which patients require urgent referral to haematology and which may have monoclonal gammopathy of undetermined significance (MGUS), where only a small proportion will need ongoing monitoring in secondary care.

Interpreting initial myeloma tests can be challenging, particularly when results arrive without clear actions. This Wales-adapted Myeloma Diagnostic Tool brings together key information to support confident decision-making in primary care, including:

• When to suspect myeloma based on symptoms and blood test findings.
• The core investigations required for suspected myeloma.
• How to interpret paraprotein, serum free light chain and related results.
• When urgent referral to haematology is needed and when repeat testing or secondary care follow-up is appropriate.

This tool has been locally adapted for Welsh healthcare services with support from haematologists in Wales. It reflects regional pathways while aligning with national guidance and is available in both English and Welsh to support earlier myeloma diagnosis