Myeloma Nurse Guide – Bispecific antibodies

The Myeloma Nurse Guide – Bispecific antibodies is an essential resource for nurses supporting people with relapsed or refractory myeloma. Bispecific antibodies work by bringing T-cells into close contact with myeloma cells, activating the immune system to kill the cancer.

While these treatments open up new opportunities, they also come with specific challenges. Nurses are central to recognising and managing side effects such as cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), infection risk, and gastrointestinal or skin toxicities. Careful monitoring, patient education and timely intervention are vital to ensure safe and effective care.

This guide brings together practical information on:

• Step-up dosing and pre-medications.
• Monitoring and grading of CRS and ICANS.
• Infection prevention, including vaccination and prophylaxis.
• Managing gastrointestinal, skin and nail toxicities.
• Supporting patients with fatigue and other common side effects.

Developed to enhance knowledge, inform practice and support nurses to deliver high-quality treatment and care, the guide is designed to be a trusted resource in clinical settings.